Shop Featured Products (click to view) | FREE Domestic Shipping $100+

Free Consultation

Overactive Diamine Oxidase Enzyme: A Comprehensive Guide

schedule your Consultation NOW
a woman sneezing

Introduction: The Role of Diamine Oxidase Enzyme

Diamine Oxidase (DAO) is a crucial enzyme that plays a significant role in the regulation of histamine levels in the body. It is primarily responsible for breaking down histamine, a compound involved in local immune responses and acting as a neurotransmitter. 

When the DAO enzyme is overactive, it can lead to a variety of health implications. This article aims to provide a comprehensive understanding of what it means for the DAO enzyme to be overactive and how it impacts the body’s histamine levels and immune response.

Understanding Diamine Oxidase Enzyme Overactivity

DAO enzyme overactivity refers to the condition where the enzyme is excessively active, leading to lower levels of histamine in the body. This can cause a variety of symptoms, including allergic rhinitis, atopic dermatitis, and chronic urticaria. The causes of DAO enzyme overactivity can range from genetic factors to bacterial overgrowth in the gastrointestinal tract.

The Role of Histamine in DAO Enzyme Overactivity

a woman has colds

Histamine is a biogenic amine involved in local immune responses, regulation of physiological function in the gut, and acting as a neurotransmitter. When released by immune cells, histamine can cause an allergic response, leading to symptoms such as itching, sneezing, and hives. 

In the case of DAO enzyme overactivity, the histamine levels in the body are significantly reduced, which can lead to a range of health issues, including a weakened immune response and increased susceptibility to infections.

The Role of Gut Health in DAO Enzyme Overactivity

Gut health plays a significant role in DAO enzyme levels. A healthy gut contributes to balanced  histamine levels, while issues like bacterial overgrowth can lead to DAO enzyme overactivity

Maintaining a healthy gut involves a balanced diet, regular exercise, and avoiding triggers that can disrupt gut health, such as stress and heavy metals.

Diagnosis of DAO Enzyme Overactivity

Diagnosing DAO enzyme overactivity involves a series of tests to measure the levels of histamine and DAO in the body

Medical professionals play a crucial role in diagnosing this condition, often relying on symptoms of histamine intolerance and the patient’s response to a low-histamine diet for initial clues.

Treatment and Management of DAO Enzyme Overactivity

Managing DAO enzyme overactivity often involves dietary changes, particularly adopting a low-histamine diet. This means avoiding histamine-rich foods and opting for foods that do not trigger the release of histamine. 

In some cases, medications and supplements that inhibit histamine production or block histamine receptors may also be recommended.

Living with DAO Enzyme Overactivity

Living with DAO enzyme overactivity can be challenging, but with the right management strategies, people with histamine intolerance can lead healthy lives. 

This involves being mindful of histamine foods, understanding the symptoms of histamine intolerance, and seeking professional help when necessary.

FAQs Diamine Oxidase Enzyme Overactive

What are the symptoms of histamine intolerance? 

Symptoms of histamine intolerance can range from headaches and hives to digestive issues and chronic fatigue.

What foods are high in histamine? 

Foods high in histamine include fermented foods, aged cheeses, alcohol, and certain types of fish.

What is a low-histamine diet? 

A low-histamine diet involves avoiding foods that are high in histamine or trigger the release of histamine. This includes fermented foods, alcohol, and certain types of fish.

What is the role of the DAO enzyme in the body? 

The DAO enzyme is responsible for breaking down histamine in the body, helping to regulate histamine levels and maintain a healthy immune response.

What causes DAO enzyme overactivity? 

DAO enzyme overactivity can be caused by a variety of factors, including genetic factors, bacterial overgrowth in the gastrointestinal tract, and certain medications.


Understanding DAO enzyme overactivity is crucial for managing histamine levels and maintaining a healthy immune response

Whether you’re dealing with allergic rhinitis, irritable bowel syndrome, or mast cell activation syndrome, understanding the role of the DAO enzyme and histamine in your body can help you manage your symptoms and improve your quality of life.

We are offering 30 minutes for free to talk to one of SeeBeyond's Functional Medicine Practitioners to create a personalized regimen.

Fill out the form below to schedule your consultation.

Request Consultation - Consultation Popup