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What is Histamine Intolerance and How Does it Relate to Diamine Oxidase and Histamine N-methyltransferase?

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Understanding the Relationship between Enzymes and Histamine Intolerance

Have you ever felt bloated or nauseous after eating certain foods? Felt fatigue or irritability for no reason? If so, you may be experiencing symptoms of histamine intolerance, a condition in which your body has trouble breaking down histamines. 

Histamines are neurotransmitters found in foods like wines, aged cheeses, pickled foods, nuts, and cured meats that help regulate many bodily functions when metabolized properly. However, an impaired enzyme system, especially relating to Diamine Oxidase (DAO) and Histamine N-methyltransferase (HNMT), can lead to excess histamine consumption and the onset of intolerances. 

DAO and HNMT are crucial enzymes responsible for metabolizing the majority of dietary and inflammatory histamines in your gut. When levels of these enzymes drop, unused amounts of histamines are absorbed into the bloodstream, triggering an inflammatory response and resulting in common symptoms like bloating, diarrhea, fatigue, headaches, and skin rashes. 

The Role of DAO in Histamine Metabolism and Intolerance

As we discussed, Diamine Oxidase (DAO) is one of the primary enzymes responsible for breaking down excess histamines in the body. DAO works by degrading histamines into harmless byproducts that are excreted in urine. When DAO is functioning properly, histamines are metabolized efficiently and do not accumulate to levels that cause issues. 

However, if DAO becomes impaired or deficient for any reason, it cannot keep up with the histamines entering your system through food and inflammation. Unused histamines then overflow into the bloodstream, triggering an inflammatory response that leads to symptoms like bloating, rashes, headaches, and fatigue. 

The only way to effectively manage histamine intolerance is through reducing histamine load by following a low-histamine diet. Limit or avoid foods high in histamines such as aged cheeses, pickled foods, cured meats, nuts, seeds, dried fruits, and alcoholic beverages. Instead, eat fresh fruits and vegetables, lean proteins, and whole grains. You can also take a DAO supplement to help boost enzymatic activity, although diet modification should be your first step.

Key Points on DAO and Histamine Intolerance

The Role of HNMT in Histamine Metabolism and Intolerance

HNMT is another key enzyme responsible for degrading histamines in the body. It works by converting histamines into non-inflammatory byproducts that can be more easily excreted. HNMT helps maintain balance by preventing excess histamine buildup, particularly in areas where inflammation often occurs like the lungs, skin, and intestines. 

Reduced HNMT activity or deficiency can lead to histamine intolerance symptoms, especially in patients with conditions marked by inflammation such as asthma, atopic dermatitis, and food allergies. When HNMT cannot break down histamines quickly enough, they overflow into tissues and trigger an inflammatory cascade. This results in symptoms like wheezing, rashes, itching, and diarrhea. 

Studies show HNMT activity and expression are impaired in asthma and atopic dermatitis patients, correlating with higher histamine levels in cells and blood. Supplementing with HNMT or reducing histamine intake may help provide relief by improving breakdown and regulation. However, more research is needed to definitively prove HNMT’s role in these conditions and establish treatment recommendations. 

Diagnosing and Managing Histamine Intolerance

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Diagnosing histamine intolerance typically begins with an elimination diet where you remove potential trigger foods high in histamines for several weeks to observe symptom relief or worsening. Keeping a food journal can help identify problem foods. Urinary histamine tests may also point to excess levels, but an elimination diet is considered the gold standard. 

Reducing histamine intake through diet modifications is the most effective treatment. A low-histamine diet limits aged cheeses, preserved meats, nuts, seeds, dried fruits, liquors, and vinegar-based foods. Eating more fresh fruits and vegetables, lean proteins, and whole grains can help restore balance. If symptoms do not significantly improve with diet alone, targeted supplements like DAO or HNMT may provide additional support

Excessive dietary histamines have been linked to chronic inflammation, autoimmune disorders, skin conditions, digestive issues, fatigue and mood changes. By managing histamine levels through diet and lifestyle changes, you can decrease inflammation, improve symptoms, and promote overall wellness and health. It is important to find the right balance of histamines that works for you to avoid deficiency or excess. 

In summary, diagnosing histamine intolerance typically starts with an elimination diet followed by testing as needed. The foundation of management is reducing histamine intake from foods that trigger symptoms while balancing essential histamines for health. Dietary modification and targeted supplements may provide relief, but balance is key. The adverse effects of excess histamine in inflammation and well-being highlight the importance of properly diagnosing and addressing histamine intolerance

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