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An Exploration of the Role and Significance of Diamine Oxidase Enzymes in Histamine Intolerance

Histamine intolerance is a relatively misunderstood medical condition but a common issue that influences the daily lives of many. The digestive tract, a crucial component in histamine metabolism, hosts an enzyme named Diamine Oxidase (DAO), primarily responsible for histamine degradation.

This article will examine high-quality DAO enzymes, their role in managing histamine levels, and their potential in the treatment of histamine intolerance.

Histamine Intolerance: Understanding the Basics

Histamine is a compound involved in various physiological processes, including cell signaling and allergic reactions. However, excessive amounts of histamine in the body can lead to histamine intolerance. This can lead to symptoms such as abdominal pain, itchy skin, a runny nose, and migraine attacks.

Histamine concentrations can increase due to several factors such as the consumption of foods rich in histamines, bacterial overgrowth in the gastrointestinal tract, or a deficiency in histamine-degrading enzymes, primarily DAO. In individuals with a DAO deficiency, the normal breakdown of histamine is disrupted, leading to an accumulation of histamine and the manifestation of uncomfortable symptoms.

Symptoms of histamine intolerance may include:

  • Headaches or migraines
  • Nasal congestion or sinus issues
  • Fatigue
  • Itchy skin
  • Hives
  • Digestive issues
  • Irregular menstrual cycle
  • Nausea
  • Vomiting
  • Abdominal cramping
  • Tissue swelling
  • High blood pressure
  • Irregular heart rate
  • Anxiety
  • Difficulty regulating body temperature
  • Dizziness

Histamine-Rich Foods

Certain foods, particularly those that are fermented, aged, dried, or processed, are high in histamines. Some of these include:

  • Cheeses
  • Yogurt
  • Sauerkraut
  • Kimchi
  • Champagne
  • Dried fruits
  • Legumes
  • Processed meats

Vinegar, along with foods containing vinegar like salad dressings, ketchup, mayonnaise, relishes, pickles, and sauces, are high in histamine, too. This is due to vinegar’s characteristic as a histamine liberator, causing mast cells to release histamine. Not to be forgotten, alcohol is also a histamine-rich beverage.

Histamine-Managed Foods

If you are looking to incorporate low-histamine foods into your diet, there are several options available. Fresh meat, certain types of fresh or frozen fish, chicken, eggs, and most fresh fruits are reported to have lower histamine levels. Additionally, certain foods such as aloe vera, capers, hibiscus, manuka honey, monk fruit powder, and spirulina are known for their anti-inflammatory or histamine-stabilizing properties, offering further support in managing histamine levels.

The cooking method can also significantly influence histamine levels. Therefore, it’s suggested to boil or poach fresh or frozen meat to keep histamine levels low. However, it should be noted that low-histamine diets can be extremely restrictive and may cause malnutrition.  


Histamine intolerance is often misdiagnosed due to its common symptoms with other conditions, including food allergies and bacterial overgrowth. Patients with histamine intolerance experience an adverse reaction to histamine-rich foods, leading to an allergic-like response without the involvement of the immune system’s IgE antibodies, differentiating it from a classical food allergy.

Histamine reactions can be exacerbated by artificial colors and artificial sweeteners, which are common in our daily diet. Furthermore, alcohol and certain medications can inhibit DAO activity, further intensifying histamine intolerance symptoms.

High-Quality DAO Enzymes: The Gatekeepers of Histamine Levels

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Located in the intestinal mucosa, DAO, and the Histamine N-Methyltransferase (HNMT) enzyme play a significant role in the metabolism of histamine. Deficiency in levels of these enzymes, especially DAO, is closely linked with histamine intolerance.

However, the enzymatic activity of DAO is influenced by various factors. These include:

Nutrient DeficiencyImpairs DAO enzyme activity, particularly Vitamin B6, Vitamin C, and CopperThese nutrients are essential for the proper functioning of DAO. When there is a deficiency, the activity of DAO is decreased, resulting in a reduced ability to break down histamine effectively.
Chronic DiseasesReduces DAO activity, especially in cases of inflammatory bowel diseaseInflammation and damage to the gastrointestinal tract can disrupt the normal functioning of DAO, leading to a decrease in its activity. As a result, histamine levels can accumulate, leading to an increased histamine response and potential allergic-like symptoms.
Genetic MutationsDecreases DAO function, leading to impaired histamine breakdownSome individuals may have genetic variations that result in decreased DAO function. This reduced activity impairs the breakdown of histamine, leading to a higher concentration of histamine in the body. 

Dietary Modifications and Supplements: A Holistic Approach

Medical professionals often recommend a low-histamine diet for people with histamine intolerance. This includes avoiding high-histamine foods and foods containing artificial preservatives, colors, or sweeteners, and instead focusing on a daily diet rich in fresh, unprocessed items.

Leading DAO Supplements

Supplementing your diet with DAO enzymes can assist in managing histamine levels. Here are the leading DAO supplements that can aid you in achieving healthy histamine levels:

1. SeeBeyond DAO-HIST

SeeBeyond DAO-HIST is a patented enzyme formula designed to support the breakdown of food-derived histamine. It’s potentially beneficial for mitigating symptoms related to histamine intolerance and enhancing your body’s production of DAO enzymes. Other active ingredients include microcrystalline cellulose, HPMC (capsule), sucrose, ascorbic acid, hydrated magnesium silicate, polyvinylpolypyrrolidone, rice starch, and shellac.

For optimum results, it’s recommended to pair this dietary supplement with a low-histamine diet. Adopting new lifestyle and eating habits can be a highly effective approach to managing high histamine levels. Our team of doctors can provide customized advice for a low-histamine diet that complements DAO supplements well. Get in touch with us today!

2. OmneDiem Histamine Digest

OmneDiem Histamine Digest provides Diamine Oxidase (DAO), the key enzyme responsible for neutralizing histamine in the digestive tract. Consuming OmneDiem Histamine Digest before meals or drinks high in histamine can help protect against digestive histamine sensitivity and prevent related reactions.

3. Histamine Block Plus

Histamine Block Plus offers a comprehensive blend of seven essential nutrient cofactors and potent antioxidants, supporting total histamine metabolism in every cell. Its main benefits include promoting a healthy response to high-histamine foods, enhancing histamine processing with the help of cofactor nutrients, and it is ideal for supporting protocols for histamine intolerance.

Concluding Thoughts

High-quality DAO enzymes represent a promising frontier in the battle against histamine intolerance. While the road to understanding is paved with ongoing clinical studies and research, it’s clear that the potential of these enzymes, combined with dietary modifications and proper supplementation, can make a substantial difference in the lives of those struggling with histamine intolerance.

Remember, managing histamine intolerance is about balance – balancing your diet, your enzyme levels, and ultimately, your health. The discovery of high-quality DAO enzymes could be the key to unlocking this balance for many. 

Empower Your Health Journey with SeeBeyond Shop’s High-Quality DAO-HIST

At SeeBeyond Shop, we believe in the power of knowledge and the efficacy of personalized wellness strategies. We bring together expertise in nutritional science to help identify if you may be experiencing a DAO deficiency, guide you through necessary diagnostic steps, and create a custom supplement plan that includes our top-tier DAO-HIST supplements.

Rebalancing your health isn’t typically a quick fix – it’s a journey.  With high-quality DAO supplements such as the DAO-HIST, it’s possible to restore balance in your DAO levels, relieve symptoms, and even reverse the effects of histamine intolerance. 

Engage with our team of medical professionals and digestive health experts at SeeBeyond Shop. It’s time to balance your enzymes, manage your histamine levels, and rediscover the vibrant health you deserve. Contact us today to get started!

We are offering 30 minutes for free to talk to one of SeeBeyond's Functional Medicine Practitioners to create a personalized regimen.

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