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The Potency of DAO Enzyme

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gut health

Mitigating Histamine Intolerance and Elevating Digestive Health with DAO Supplementation from Thorne and SeeBeyond Medicine

The human body is an intricate biological masterpiece, its underlying processes operating akin to a complex machine. Among these systems, the digestive tract from mouth to colon presents a captivating study, playing a critical role in our survival through nutrient extraction and waste elimination.

Housing a bustling metropolis of bacterial populations both beneficial and detrimental, the gastrointestinal tract necessitates balance for our health and overall wellness. An enzyme, diamine oxidase (DAO), is integral to this equilibrium, specifically when it comes to managing the consumption of histamine-rich foods.

Unveiling Diamine Oxidase

DAO is the enzyme responsible for breaking down and metabolizing histamine, a compound involved in immune responses and inflammation. The small intestine, abundant in DAO, leverages this enzyme to regulate histamine levels.

In individuals with deficient DAO activity, histamine can accumulate, causing symptoms like headaches, abdominal pain, atopic dermatitis, and issues with the digestive system. This deficiency often manifests as histamine intolerance, a medical condition where the body is unable to break down dietary histamines properly.

Histamine: A Closer Look

When we consume histamine-rich foods, our bodies release histamine. This process can trigger an immune response. An overabundance of histamine in the body caused by either excessive histamine foods or a lack of degradation of histamine can lead to histamine intolerance.

The body typically maintains the levels of histamine through the action of enzymes such as DAO. People with histamine intolerance may have lower levels of this enzyme, hindering the body’s capacity to break down food-derived histamine. This imbalance may lead to a plethora of symptoms, including digestive disorders, skin rashes, and frequent headaches.

Conditions like celiac disease have been linked with reduced DAO activity, underscoring the importance of maintaining proper enzymatic function. That’s where DAO supplements step into the picture.

DAO Oral Supplementation

DAO enzyme supplements are designed to help people manage their histamine intolerance. These promote the beneficial effects of DAO, ensuring histamine-rich foods are efficiently broken down, mitigating any negative health effects.

DAO enzymes play a crucial role in controlling the body’s histamine levels. By supporting the body’s natural ability to break down histamine, DAO supplements can help manage symptoms associated with histamine intolerance.

Histamine intolerance makes people with this condition struggle with the release of histamine in their bodies due to the consumption of histamine-rich foods. Supplementing with DAO can provide these individuals with much-needed relief, working in tandem with their bodies to reduce histamine levels.


Digestive Health

Support DAO’s vital function within the small intestine contributes significantly to our digestive health. Abundant in the mature cells lining our small intestine, the DAO enzyme facilitates the breakdown of histamine. This activity is especially potent at the end of these cells.

A healthy amount of DAO signifies a properly functioning small intestine. This promotes a robust digestive system, which in turn can contribute to better nutrient absorption, regular bowel movements, and overall wellness.

Mitigating Histamine-Related Conditions

The accumulation of histamine can trigger a range of symptoms like headaches, digestive issues, and skin problems. By supplementing with DAO, the body’s capacity to degrade histamine is boosted, thus managing the symptoms of histamine intolerance. 

Relief from Allergy Symptoms

Histamine is a primary contributor to allergic reactions. When an allergen enters the body, the immune system responds by releasing histamine, resulting in symptoms like runny nose, watery or itchy eyes, skin rashes, and in severe cases, anaphylaxis.

DAO enzyme assists in breaking down and removing histamine from the body, potentially alleviating these allergy symptoms. Thus, maintaining appropriate levels of DAO can play a crucial role in managing allergy symptoms, making supplements a valuable tool for those with certain types of allergies.

Choosing the Right DAO Enzyme Supplement

a pharmacist checking two pill bottles

When selecting the right DAO enzyme supplement, consider Thorne’s comprehensive approach to gut health and SeeBeyond Medicine’s specialized DAO-HIST supplement, both designed to support and enhance your body’s natural DAO production and function. These supplements offer a holistic approach to managing symptoms of histamine intolerance and promoting overall well-being.

SeeBeyond Medicine

SeeBeyond Medicine, led by Dr. Hyun Joon Lee, MD, is a holistic healthcare provider that combines the best of modern medicine and natural treatments. Our company sees patients as partners, focusing on harnessing functional medicine to help every patient achieve optimal health.

Since 2008, we have been mastering the application of functional medicine, moving away from prescription medication and towards nutrition, exercise, supplements, detoxification, and general holistic healing. SeeBeyond Medicine prides itself on being an all-in-one practice for supplements, skincare treatments, and medical procedures ranging from weight loss to anti-aging treatments to IV therapy.

Product Offered

SeeBeyond Medicine offers a unique DAO supplement called DAO-HIST. This supplement is designed to help manage symptoms of histamine intolerance by supporting healthy DAO enzyme function.

Daily DAO supplementation with DAO-HIST can help with a variety of health conditions such as migraine attacks, rashes, and digestive problems. The supplement contains a patented enzyme formula that supports the degradation of food-derived histamine, potentially curbing symptoms related to histamine intolerance and improving the body’s DAO enzyme production.


Thorne is a health and wellness company dedicated to improving the health and well-being of people worldwide. With a commitment to pure, high-quality, research-based, clean formulas, Thorne is a trusted provider of supplements that cater to various health needs. The company’s mission is to redefine how we prevent and manage health by removing obstacles to good health. Thorne’s commitment to integrity, transparency, and testing ensures that each product is held to the highest standards of quality and safety.

Products Offered

In the realm of gut health, Thorne offers a wide range of supplements designed to support a healthy gut microbiome. These products are formulated to address various aspects of gut health such as nutrient absorption, intestinal barrier function, and microbiota balance.

While Thorne doesn’t offer a direct DAO supplement, their gut health supplements can indirectly support the body’s DAO production by promoting a healthy gut environment. Products like “GI-Encap” for soothing GI tract lining, “FloraMend Prime Probiotic” for gut microbiota health, and “EnteroMend” for healthy inflammatory response in the GI tract, all contribute to a comprehensive approach to gut health.

Comparison: Thorne vs. SeeBeyond Medicine

While both Thorne and SeeBeyond Medicine offer solutions to manage histamine intolerance, their approaches differ. Here is a quick comparison between the two providers:

 ThorneSeeBeyond Medicine
ApproachBroad approach to gut healthTargeted DAO supplementation
ProductsRange of gut health supplementsDAO-HIST supplement
BenefitsSupports overall gut health, which can indirectly support DAO productionEnhances DAO activity to manage histamine intolerance

The choice will depend on the individual’s specific needs and health goals. A consultation with a healthcare provider can provide guidance on the best approach.

Our Consultation Process

A consultation with SeeBeyond Medicine begins with a thorough evaluation of your health history, symptoms, and lifestyle. Our team then works with you to develop a personalized treatment plan that may include dietary changes, lifestyle modifications, and supplements like DAO-HIST. Throughout the process, we monitor your progress and adjust the plan as needed to ensure you’re moving toward your health goals.

Embrace Wellness with SeeBeyond Medicine

In the journey to manage histamine intolerance, choosing the right DAO supplement and provider is crucial. At SeeBeyond Medicine, we offer a comprehensive approach to wellness, providing our unique DAO-HIST supplement designed to enhance your body’s natural DAO production and function. 

Don’t let histamine intolerance dictate your life. Make an informed choice with SeeBeyond Medicine. Schedule a consultation today and discover how our specialized DAO-HIST supplement can help you step into a healthier, more balanced lifestyle. Elevate your digestive health and mitigate histamine intolerance with the right DAO supplement from SeeBeyond Medicine.

We are offering 30 minutes for free to talk to one of SeeBeyond's Functional Medicine Practitioners to create a personalized regimen.

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